Is the program that I have been using for over a year.  Has never corrupted my registry.  Seems to do its job.  Helps with programs opening faster, especially Outlook.  Also it has a fully functional 30 day free trial.  If it doesn't suit you your not out anything.

It can be found here.

 http://www.macecraft.com/jv16powertools2006/

I bought this program because it was recommended by Fred Langa.  He did a test on 10 different registry clearners and jv16 PowerTools came out on top.  His test of the registry cleaners can be found here.

http://www.informationweek.com/story/showArticle.jhtml;?articleID=171203805