My grandma and her daughters (my aunts) took levothyroxin.  I guess if you can dose it just right you can set your metabolism to make you rail thin and high activity level.  If it is too low you feel like you can’t get up off of the chair.

I have had two noncancerous parathyroid tumors.  That will knock you down and it doesn’t happen right fast, it sneaks up on you over several years and put the whammy on you nice and slow.  In my case the tumor made the parathyroid make so much hormone to put calcium into my blood that it overwhelmed the thyroid’s ability to keep calcium levels down (via making calcitonin and also suppressing D25 production in the kidney’s).  The diagnostic criteria is stones, bones, moans, with psychiatric overtones - you get kidney stones, your bones ache, your muscles cramp and hurt, you can’t sleep, your attitude sucks/mild depression/lots of frustration, eventually you just get confused and can’t think due to high calcium levels.  Just easily defeated in trying to accomplish tasks.  But you can just think you are getting older and grumpier for a long time. Then when the tumor came out the calcium dropped to the floor and there were shakes and tremors and all sorts of fun until it all leveled out 6 weeks or more later.  Now feeling better than I have for years.

One possible thing to also check into is Hashimoto’s syndrome or disease, which is commonly associated with thinning eyebrows.  It is an inflammatory autoimmune disease you can address with diet.  I was told to check T3, T4, and TPO if I felt like that was still a possibility after my tumor came out.  Acquaintance had it and inflammation, weight gain, puffiness, general aches, and some mental confusion/slowness and negativity were symptoms mentioned. 

I would tell my spouse or sibling immediately because when you feel that bad and you don’t know it, you need someone to push forward on your behalf to get in to see your GP and get a referral to an endocrinologist, which usually means a 8-week wait and a drive to the big city.  Or you can feel terrible for months and wait around to take action, which I don’t advise.

I don’t run to the Dr for every little thing but I sure wished I had started a couple years earlier this last go around with parathyroid fun.  It was just plain bad for a long time.